Aston Villa, Everton, Tottenham Hotspur, Atalanta and AS Roma are all tracking Scienza's situation, according to Sky Sport Germany, with Southampton setting an asking price of €30m for a player they signed for just €9m from FC Heidenheim last summer.
Scienza contributed 17 goal involvements in 37 appearances across Southampton's relegation season — a remarkable individual output for a player in a struggling side. His directness, close control and ability to create chances from wide positions gave him a profile that stood out in what was otherwise a difficult collective campaign for the Saints.
Palmeiras and Flamengo have also registered interest from Brazil, offering an alternative path for a player who has never played professional football in his home country and may be open to an emotional return.
The transfer arithmetic for Southampton is straightforward. A sale at anything approaching the €30m asking price would represent a profit of over €20m on a player they acquired in their last Premier League window, generating funds that become available for a Championship rebuild.
Scienza has one year remaining on his contract, which gives the club a degree of leverage. Whether a Premier League side returns is the key question — of the five clubs linked, Villa and Tottenham represent the most realistic top-flight destinations.