The 25-year-old, signed from Tottenham for around €31 million plus bonuses to replace Denzel Dumfries after his move to Real Madrid under Jose Mourinho, has yet to make a single competitive appearance for Cristian Chivu's side since his summer arrival at San Siro.
According to today's edition of the Gazzetta dello Sport, his recovery is progressing very well indeed, but a return to full training and eventual match action is likely to be around a month away, almost certainly after next week's international break.
Spence picked up a minor physical issue immediately after England's World Cup campaign, which ended in third place this summer, and the problem effectively wiped out his entire pre-season programme alongside his new teammates.
Nothing serious is understood to be involved, but the setback meant he arrived at Inter well behind the rest of the squad in terms of match fitness, and the club have opted to take a cautious, individualised approach to his rehabilitation rather than rush him back into contention prematurely.
In the meantime, Andy Diouf has continued to deputise capably on the right side of Inter Milan's defence in Spence's absence, offering what reports describe as strong guarantees in the role and reducing the pressure on the club to rush their new signing back before he is ready.
Spence, who previously played for Genoa on loan before returning to Tottenham and eventually moving to Italy, has signed a contract with Inter running until 2031, underlining the club's long-term commitment to the England international despite the delayed start to his spell in Serie A.
Inter had been eyeing a possible involvement for Spence in the upcoming visit of Roma, but with the international break following shortly after, the club appear content to wait until the squad reconvenes before easing him into contention.
Chivu is expected to continue rotating between Diouf and other options on the right flank until his new arrival is fully ready to contribute on a consistent basis.