The 26-year-old is due in Milan to complete the formalities on Friday, according to ANSA, drawing a line under two years in London and confirming his exit from Tottenham Hotspur.
Inter Milan have agreed to pay more than €30m for the right-back, though figures vary by outlet: some reports place the fixed fee at €31.5m, with bonuses taking the total package as high as €34-35m. Spurs are understood to have wanted closer to €45m when interest in Spence intensified during the World Cup, before the two clubs steadily closed the gap over the past fortnight.
Spence becomes head coach Cristian Chivu's direct replacement for Denzel Dumfries, who left Inter for Real Madrid earlier this summer after Los Blancos triggered his release clause.
Chivu regards Spence as a rare asset who can operate comfortably on either side of defence, a trait the head coach believes suits Inter's increasingly vertical approach this season. Spence is set to sign a five-year contract that would keep him at San Siro until 2031.
The deal continues a pattern of Premier League recruitment at Inter this summer. Spence is set to become the second Englishman to join Chivu's squad in the window, after defender John Stones arrived on a free transfer, while the Nerazzurri are also pursuing Liverpool's Curtis Jones as a potential replacement for Davide Frattesi, who is closing in on a move to Lazio.
At Tottenham, head coach Roberto De Zerbi had made clear that Pedro Porro remained his first-choice right-back, leaving Spence short of regular opportunities despite his form for England and accelerating his search for a fresh challenge elsewhere.
Spence's rise has been rapid. Raised in Fulham's academy before beginning his senior career at Middlesbrough, he first caught wider attention during a loan spell at Nottingham Forest in 2021-22, where he won more duels than any other defender in the Championship and was named in the division's team of the season.
That form earned him a move to Tottenham in 2022, in a deal that could rise to £20m, though he initially struggled for regular football and was loaned out again, to Rennes, Leeds United and Genoa — the latter giving him his first taste of Serie A.
An unexpected breakthrough with England at this year's World Cup, including a start in the semi-final defeat to Argentina, transformed his standing and made him a target for one of Europe's biggest clubs.