"The important thing is that both those who start and those who come on afterwards are good," he said.
On Aurelien Tchouameni, Deschamps confirmed the midfielder remains a doubt but that he expects to be able to count on him.
"He's doing better. He's not at one hundred per cent, but this is a World Cup semi-final," he explained. Asked about the changes Luis de la Fuente might make to Spain's side, he added: "They can make changes. It's not that I make decisions based on the opponent, it depends on each player's profile."
On Lamine Yamal, the France coach made clear his side have studied Spain's strengths closely, while backing his own players to cope.
"We know our opponent's strengths, but we also have our own. Luis will have studied us. The key is whether our players can make the difference. You have to counter the opponent's qualities. Going one against one with my players isn't easy either," he said.
Deschamps also played down suggestions France have gained a physical edge from travelling fewer miles during the tournament.
"I haven't looked at Spain's flight hours. Finishing top of our group mattered for that reason. Travel is an important factor, but we're in the semi-finals. Everything plays a part: extra time, the heat. What matters is tomorrow's match," he said.
He went on to stress the importance of experience in this kind of knockout tie.
"It's a factor that helps and matters a great deal. This is the third semi-final we've faced against Spain. I hope we avoid silly mistakes, but there's always a lot of uncertainty when you talk about football," he added.
Deschamps went on to surprise many by openly naming Spain as favourites.
"I'll confirm they're favourites. Given what they've done... Apart from the first match against Cape Verde, Spain have confirmed they're the favourites. People expect a lot from Spain. They attack and defend very well. They've only conceded one goal in six matches. With the attacking quality on show, it will be a spectacular game," he said.
Warren Zaire-Emery also spoke to reporters and defended the unity of the French squad when asked about an unrelated article.
"Unfortunately I haven't read that article. We have players from different backgrounds. We're a group of every race and united, which is what matters," he said.
The PSG midfielder also spoke of his pride at reaching the semi-finals after playing minutes in the quarter-final against Morocco.
"It's a source of pride to be here. It's the most memorable match of my career," he said.
On Yamal, Zaire-Emery praised the Spanish winger while backing France's defence.
"We all know Lamine Yamal's quality, but we have very good players to stop his game," he said, before adding a message of confidence: "We are France and we fear nobody. We focus on ourselves. The match isn't played on social media or in the press, it's played tomorrow on the pitch."