Fabrizio Romano confirmed the 19-year-old's contract is already signed, with the Andalusian defender moving to Italy for a fee of €700,000 plus a 20% sell-on clause.
It continues a clear pattern of transfer activity under Cesc Fábregas, who has built his recruitment strategy around young talent from Spanish football, a market he knows intimately from his own playing career.
Como have already secured Nico Paz on a permanent deal this summer, and Cuenca's arrival represents the club's latest raid on one of Spain's leading academies as they look to build a squad capable of competing at the highest level.
Cuenca spent the first half of last season with Barcelona's B team and youth side before moving out on loan to second-tier Sporting Gijón for the second half of the campaign. His time there was disrupted by injury, restricting him to just eight appearances, but he remains highly regarded as a long-term prospect for the Spanish national team.
He arrives at Como fresh off winning the European Under-19 Championship with Spain's youth side, having come through virtually every age group of La Masia after joining the club's academy as a boy.
Born in Adamuz, in the province of Córdoba, Cuenca is a left-footed centre-back who was long considered one of the most promising defenders to emerge from Barcelona's youth setup in recent years, regarded internally as a future first-team option before injuries interrupted his progress last season.
His departure continues a familiar pattern at Barcelona, where financial constraints and a crowded pathway to the senior side have pushed several highly rated academy graduates to seek regular football elsewhere.
The move gives Como a promising defensive option as they prepare for a landmark season, with the club set to compete in the Champions League for the first time in their history — a remarkable achievement for a side that has spent only two seasons back in Serie A.
Como's ability to attract prospects of Cuenca's calibre reflects the growing reputation Fábregas has built since taking charge, with the club increasingly positioning itself as a destination for promising young Spanish players looking for regular first-team opportunities in a competitive European environment as they take their first steps on the continental stage.