It marks a significant reshaping of Xabi Alonso's squad in the closing hours of the window, with all three exits subject to the players agreeing personal terms at their new clubs.
Tottenham's push for both Mudryk and Adarabioyo comes on the back of a summer in which Spurs have already spent £380m on eight new arrivals, underlining the scale of the rebuild under new head coach Roberto De Zerbi.
Spurs are keen to secure Mudryk, 25, in order to reunite him with De Zerbi, under whom he broke through at Shakhtar Donetsk before an initial £61m move to Chelsea in January 2023. The Ukraine international has not featured competitively since November 2024, when he was provisionally suspended after an adverse finding for the banned substance meldonium.
A resolution between the Football Association and the World Anti-Doping Agency restored his eligibility to play in July, and he has not featured in a single Chelsea matchday squad since his return.
Tottenham will also sign Adarabioyo, 28, on a permanent deal, filling the gap left by Kevin Danso's departure to Sunderland on an initial loan. De Zerbi confirmed after Saturday's 2-0 home defeat to Newcastle that both Danso and Richarlison had separately asked to leave Tottenham, underlining the scale of the rebuild taking place at the club before Tuesday's deadline.
In Italy, Como have reached a verbal agreement for a season-long loan of goalkeeper Robert Sánchez, 28, who was made available after two errors in Chelsea's Premier League opener at Fulham led directly to the Blues conceding twice, despite going on to win the match 3-2.
Como, who signed defender Trevoh Chalobah from Chelsea for £31m earlier in the window, need a replacement for Noel Törnqvist, who is departing for fellow Serie A side Monza. Sánchez's likely successor at Stamford Bridge is Emiliano Martínez, signed from Aston Villa for £7.5m, whose arrival has freed Alonso to sanction the goalkeeper's exit.
Chelsea's willingness to sanction three senior departures in a single day reflects Alonso's determination to trim his squad before Tuesday's cut-off, even as questions remain over exactly who will replace Mudryk and Adarabioyo in his own plans for the run-in.