The move represents a significant step up in Manchester City's willingness to part with the 20-year-old, who has spent much of the past two years out on loan without ever managing to break into City's first-team picture.
He has had loan spells at PSV's reserve side, Nottingham Forest's under-21s, Hull City and, most recently, Sheffield Wednesday, with varying degrees of success along the way.
Ndala joined City's academy in 2016 after being brought through from Port Vale's youth ranks as a ten-year-old, in a deal reported at the time to be worth around £300,000. The left-footed winger progressed through City's age groups and was capped three times for England's under-20s, but a first-team breakthrough at the Etihad never materialised, with his most productive spell coming for City's under-18s, where he scored 17 goals and provided eight assists in 41 appearances.
Cercle Brugge, who are owned by the same investment group behind AS Monaco, are viewed as a logical destination for a player who needs regular first-team football to continue his development after a difficult run of loan spells failed to fully establish him elsewhere.
Neither club has yet confirmed the transfer, though reports in Belgium suggest the deal is in its final stages and could be completed in the coming days.
The move would mark the end of a decade-long association with City for a player once regarded as one of the club's more promising academy exports, though a first-team opportunity at the Etihad never materialised.
A permanent switch to Belgium's top flight would give him the sustained run of senior football that his loan spells were never quite able to provide, and a chance to rebuild his career away from the intense competition for places at one of the Premier League's biggest squads.