The Argentine forward's contract situation and future at the club dominated the conversation after a performance that underlined why Gian Piero Gasperini is so determined to keep him.
The 32-year-old, whose deal expires this summer and who had been linked with a move to Boca Juniors in Argentina for much of the season, delivered his most influential display in weeks, operating in a fluid role behind Donyell Malen and contributing directly to both goals.
It was his arching corner that Gianluca Mancini, Roma's captain and centre-back, met at the near post on 40 minutes to open the scoring, and his delivery from another set piece that Mancini glanced home in the 66th minute to complete a brace and seal the points.
Mancini won every aerial duel with Spanish Lazio centre-back Mario Gila across both goals, climbing above the 25-year-old defender to divert the ball beyond debutant goalkeeper Alessio Furlanetto on each occasion.
Gasperini made clear after the match that Dybala's future is being discussed at the highest level and that resolution is close.
"That is a matter for next week. The owners are here, thankfully, and everything can become easier when you get an immediate response. Both the player and the club want to continue together. I would be very happy for him, and for the many players whose contracts expire, who showed professionalism and love for the club."
Earlier in the week, reports emerged suggesting Dybala is now open to staying in Rome on a reduced salary, representing a significant shift from the situation a month ago when a departure for his boyhood club appeared to be gathering momentum.
The win was settled amid considerable drama. Wesley of AS Roma and Lazio midfielder Nicolò Rovella were both sent off in the 70th minute after a brawl that stemmed from a physical confrontation between Rovella and Roma substitute Stephan El Shaarawy, who was appearing in his final home match for the club. Evan N'Dicka was also forced off with a muscle injury early in the first half.
Roma move into fourth place on 70 points, two ahead of Juventus, who lost at home to Fiorentina on the same afternoon. They face already-relegated Hellas Verona away from home in the final round of fixtures and control their own Champions League destiny.