Aston Villa scouts have already seen the youngster in action this season, including during Benfica's 3-1 defeat by Porto at the Estádio do Dragão.
Prestianni provided an assist despite Benfica's defeat, with his side's task made more difficult by Clement Lenglet's early red card.
His performances this season have attracted further attention, with the Argentine recording eight goals and three assists in 12 appearances across all competitions.
Villa's interest is now being reported as specific rather than part of a broader scouting operation.
O Jogo reports that the Premier League club have been tracking Prestianni since the beginning of the season and were in Porto specifically to assess him during the derby.
The winger impressed despite Benfica's loss, strengthening the impression he is a player Villa could consider pursuing.
Villa could return to the market in January after strengthening their wide options during the summer, when they signed Alejandro Garnacho.
Prestianni has consequently emerged as a potential option, with the report suggesting he could be viewed as a direct replacement for his fellow Argentine.
However, Villa would face competition for his signature.
Atletico Madrid are also continuing to monitor the Benfica winger as they look to add further Argentine talent to Diego Simeone's squad.
For now, Villa's interest centres on continued assessment, with Prestianni's performances for Argentina during the international break providing another opportunity for the club's scouts to evaluate him.