Manchester United have reached an agreement in principle with Pochettino to replace Michael Carrick, who was dismissed on Thursday after the club's poor start to the season. The former Tottenham and Chelsea manager is expected to take charge of the USA's two upcoming matches against Haiti before moving to Old Trafford.
According to the Daily Mail, Pochettino will oversee both legs of the CONCACAF Nations League quarter-final, with the second fixture scheduled in Cincinnati on Tuesday. The match is expected to finish in the early hours of Wednesday morning in the UK, leaving the 54-year-old with a demanding journey to England.
BBC Sport reports that United have made formal contact with the US Soccer Federation over a release clause worth approximately £7 million. The club intend to activate it, while respecting the national team's commitments during the international window.
Pochettino is expected to arrive at United's Carrington training base on 18 or 19 November. That would leave him only a short period to work with his new squad before the trip to Liverpool on Sunday, 22 November.
The Anfield fixture will be the first of a demanding sequence for United, who are scheduled to play eight matches in 29 days across the Premier League and Champions League. The club are currently in the relegation zone after winning only once in their opening ten league games.
The appointment will also bring a new coaching team to Manchester. Pochettino is expected to be joined by trusted assistants Jesús Pérez and Miguel D'Agostino, with the cost of assembling his backroom staff taking the overall expense beyond the reported release clause.
There is little time for a gradual introduction. United need an immediate improvement after Carrick's dismissal, and the prospect of beginning against their fiercest rivals leaves Pochettino with an especially difficult first assignment.
The Argentine has experience of the Premier League from his spells with Southampton, Tottenham and Chelsea, but taking charge of a club in the relegation zone presents a very different challenge.
United will hope his arrival can provide a fresh direction, although the timing means he will have little opportunity to reshape the team before one of the biggest fixtures in the English calendar.