Manchester City are three points behind Arsenal with a game in hand and need to win to ensure the title race continues to the final day.
The weekend's spotlight fell on the decision to disallow West Ham's injury-time equaliser against Arsenal — a call that kept the Gunners five points clear and left City with no margin for error.
Ahead of Wednesday's clash with Crystal Palace, Guardiola addressed the VAR controversy at his pre-match press conference without prompting.
"We lost the two finals of the FA Cup because the referees didn't do their jobs they should do, even the VAR. When this happens it is because we have to do better, not blame the referees or VAR. I never trust anything since I arrived a long time ago. Always I learned you have to do it better, be in a position to do it better because VAR is a flip of a coin."
He said the club's response to any perceived injustice must be internal.
"VAR was not installed last weekend. It has been here for many years, we adapt, and everybody knows it. The only thing we can do is do it better — that is only in your control."
The two FA Cup incidents Guardiola cited without being asked were the 2024 final, where Crystal Palace beat City and goalkeeper Dean Henderson was not sent off for a handball, and the 2025 final, where City lost to Manchester United amid arguments that both Lisandro Martínez and Kobbie Mainoo fouled Erling Haaland in the penalty area.
Wednesday's Palace referee is Stuart Atwell — the official in charge of last year's FA Cup final. Guardiola confirmed he expects Crystal Palace to rotate heavily given their Conference League final against Rayo Vallecano in Leipzig on May 27, and backed head coach Oliver Glasner's right to manage his squad as he sees fit.
"Leave the managers to do what they have to do. The less the Premier League is involved in all the decisions, will be better for all of us."