Barcelona only need a draw against Real Madrid to be confirmed as La Liga champions.
The Brazilian winger has not featured since the international break but is expected to be involved at some level on Sunday, whether from the start or from the bench.
His return would represent a significant threat to a Real Madrid side that has conceded seven goals to the 31-year-old across his last five meetings with Los Blancos — a record that makes him arguably the most damaging individual player in modern Clásico history.
Speaking before his injury intervened, Raphinha addressed the prospect of clinching the title against their greatest rivals.
"To be honest, what is special for me is winning La Liga, regardless of the opponent. For the fans, for those who have been at the club the longest, beating our biggest rival to do it is something very special. But for me, the most important thing is winning the league. If it has to be against them, even better."
Barcelona lead Real Madrid by 11 points in the table with four matches remaining. A point at Camp Nou confirms the title with three games still to play. Hansi Flick's side have won all four Clásicos contested this season, including the Supercopa de España final in January when Raphinha's second-half winner settled a 3-2 thriller in Jeddah.
This season Raphinha has contributed 19 goals and seven assists in 31 La Liga appearances — a reduction on his extraordinary 34-goal, 22-assist output across all competitions last term but still among the highest returns of any wide forward in European football.
The Blaugrana coaching staff have given no indication they will rush his return, but his motivation to be on the pitch for a potentially historic occasion is understood to be total.